Practical treatment using mitotane for adrenocortical carcinoma
نویسندگان
چکیده
منابع مشابه
Clinical results of the use of mitotane for adrenocortical carcinoma.
Mitotane (o,p'-DDD) acts mainly as an inhibitor of intramitochondrial pregnenolone and cortisol synthesis. Its adrenolytic effect depends on metabolic activation due to conversion to o,p'-DDA and o,p'-DDE. The drug has been used for 40 years in the treatment of adrenocortical carcinoma, mainly its regional and metastatic stage, as an adjuvant to surgical resection of the tumor. In the medical l...
متن کاملPregnancy in a patient with adrenocortical carcinoma during treatment with Mitotane - a case report.
We present the case of a female patient with virilising adrenocortical carcinoma treated surgically who conceived during adjuvant treatment with mitotane. We discuss the frequently erroneous routine treatment with oral hormonal contraception without thorough differential diagnosis in female patients with oligo-/amenorrhea and subsequent delay in the proper diagnosis of adrenocortical carcinoma.
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Cancer of the adrenal cortex (ACC) is a rare endocrine malignancy with limited treatment options. Patients typically present with autonomous hormonal overproduction and/or a large abdominal mass. Hormonal assays and medical imaging can be diagnostic, but urinary steroid profiling might be a more sensitive technique to assess malignancy in adrenal tumours. The stage of the disease at diagnosis i...
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respond to metoclopramide, domperidone, ranitidine, amantadine, levodopa, carbamazepine, clonidine, prazosin, haloperidol, methysergide, or metoprolol. He improved slightly with the application of scopolamine patches, which had to be stopped because of side-effects. Intramuscular chlorpromazine (25 mg) would sometimes prevent attacks for up to a week. He was prescribed baclofen 10 mg, three tim...
متن کاملEtoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced adrenocortical carcinoma: a large prospective phase II trial.
To investigate the activity of etoposide, doxorubicin, and cisplatin plus mitotane in the management of advanced adrenocortical carcinoma (ACC) patients, 72 patients with measurable disease not amenable to radical surgery were enrolled in a prospective, multicenter phase II trial. EDP schedule (etoposide 100 mg/m(2) on days 5-7, doxorubicin 20 mg/m(2) on days 1 and 8, and cisplatin 40 mg/m(2) o...
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ژورنال
عنوان ژورنال: Current Opinion in Endocrinology & Diabetes and Obesity
سال: 2014
ISSN: 1752-296X
DOI: 10.1097/med.0000000000000056